Thank you Strator and zEitEr for your comments, I greatly appreciate it. I can see I will definitely need to spend some time thinking about the benefits and whether they apply to my situation.
zEitEr your advice is right on the mark as usual

. I currently run a mix of WordPress, Drupal and static HTML websites (no streaming/gaming) and am not experiencing any specific issues (e.g. low memory, slow response times etc.). However, I have been very interested in Nginx since I first learned of its capabilities - mainly for my customers benefit.
I have had several potential customers ask if I provide "WordPress Hosting" like some of the managed providers. I explain that aside from some of the advanced features (staging environment, automation etc.), the DA platform can provide very similar performance. This being the case I am always looking for ways of increasing overall performance. However, from what you have explained I can see that Nginx may or may not be the best for all use cases.
Your brute-force cutomizations for Nginx sound very intesting. Other than ConfigServer notifications for failed FTP/SMTP authentication attempts, I only receive messages due to excessive memory usage from WP sites. For some customers I have resolved this by disabling WP Cron and setting up a Cron job within DA. However, this isn't possible for everyone. I will definitely keep this in mind and be in touch if I decide to move forward with Nginx.
I definitely need to follow your advice and do some testing. I have a spare DA license and can spin up a VM to learn more about getting Nginx+Apache configured. This will give me a chance to see how everything works together and to see if it would apply to my situation.
Thank you both again for your comments and suggestions!