Apache error logs full of file does not exist errors.

[computerlady911]

My apache error logs is full of:

[Sat Feb 03 18:50:41 2007] [error] [client 64.173.224.9] File does not exist: /home/da01/domains/sharedip/trustm3now
[Sat Feb 03 18:50:41 2007] [error] [client 64.173.224.9] File does not exist: /home/da01/domains/sharedip/404.shtml
[Sat Feb 03 20:07:58 2007] [error] [client 193.35.10.55] File does not exist: /home/da01/domains/sharedip/trustm3now
[Sat Feb 03 20:07:58 2007] [error] [client 193.35.10.55] File does not exist: /home/da01/domains/sharedip/404.shtml
[Sat Feb 03 20:16:04 2007] [error] [client 209.173.7.98] File does not exist: /home/da01/domains/sharedip/trustm3now
[Sat Feb 03 20:16:04 2007] [error] [client 209.173.7.98] File does not exist: /home/da01/domains/sharedip/404.shtml
[Sat Feb 03 20:16:41 2007] [error] [client 206.78.172.226] File does not exist: /home/da01/domains/sharedip/trustm3now
[Sat Feb 03 20:16:41 2007] [error] [client 206.78.172.226] File does not exist: /home/da01/domains/sharedip/404.shtml
[Sat Feb 03 20:25:51 2007] [error] [client 70.88.24.58] File does not exist: /home/da01/domains/sharedip/trustm3now
[Sat Feb 03 20:25:51 2007] [error] [client 70.88.24.58] File does not exist: /home/da01/domains/sharedip/404.shtml
[Sat Feb 03 20:50:35 2007] [error] [client 167.191.250.81] File does not exist: /home/da01/domains/sharedip/trustm3now
[Sat Feb 03 20:50:35 2007] [error] [client 167.191.250.81] File does not exist: /home/da01/domains/sharedip/404.shtml

I went back 500 lines and these appear over and over. Should I block those IP address?