I have noticed in last version of DirectAdmin 1.48.3 that button for setting Safe Mode and Open BaseDir is missing in page (CMD_PHP_SAFE_MODE). You can only select domains but cannot do anything else. There is no button only "With Selected"
Picture: http://hostcom.eu/di/FEO5/directadmin_php_settings.png
Regards
Peter H
Picture: http://hostcom.eu/di/FEO5/directadmin_php_settings.png
Regards
Peter H