I guess not, because it will be a final (stable) release of DirectAdmin for CentOS 5. Also, I think that it will be supported from the next release of DirectAdmin.
There should be very little difference between requirements for CentOS4 and CentOS5. It's possible that a simple recompile on CentOS5 will be all that's required.
I'll start testing it as soon as it's made available to me. I already have a testbed server built and waiting for it.
If there are problems, then I suppose we might create a beta forum for it.
But the difference between beta OS release forums for other OS distributions and CentOS is actually quite simple: DirectAdmin is built first on CentOS/RedHat.
The other OS distributions require testing because no one knows what changes are required until they're tested.