I'm posting to verify a few things and make a suggestion:
While I recommend 2222 as the official DA submission address, since it's the one documented by DA, you can certainly change to any unused port that's unblocked, but the key is it needs to be unblocked by all your users' ISPs. So as Big Wil writes, 8080 is a good alternative port, since you can only have one.
And I wanted to clarify, that, as Big Wil also wrote, you cannot set DirectAdmin to use port 80 because only one daemon can listen to a port at a time, and the httpd daemon (apache) needs to list on port 80.
I also suggest that if you're going to use an alternate port for email you should use the port set aside in the RFCs specifically for authenticated email submission, as all ISPs should allow it:
Port 587 is reserved for authenticted email message submission; any ISP that disallows it is in violation of the RFCs.
Jeff