in the necessary transports - then I don't think any of the long winded responses in this thread would have any relevancy. Simply regex replace this statement and value with whatever we want in a post exim_conf hook.
To that end, if it helps anyone with an idea, I both customize exim.conf and use custombuild, and I do it by writing scripts for the services that I alter like this: https://github.com/mxroute/da_server_updates/blob/master/exim/update_exim.sh